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Prof. Dr. Mohsin Shah

Prof. Dr. Mohsin Shah

Prof. Dr. Mohsin Shah

Professor

Department of Physiology

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About

Biography

Dr. Mohsin Shah (1980) studied Biochemistry/Molecular Biology at Quaid-e-Azam University, Islamabad, Pakistan (2002-2004). After his MPhil research (2004-2006), on the development of Hemorrhagic septicemia vaccines, he moved to the department of Life Sciences, Gyeongsang National University, South Korea for his PhD research on drug delivery-based nano-formulations. Shortly after dissertation of his PhD thesis in 2010, he was appointed as senior postdoc researcher at Gyeongsang National University. In September 2011, he joined Khyber Medical University as research assistant professor and soon after he started to establish his own research group. As a principal investigator (PI), he is currently leading his own endocrinology and reproductive physiology research group with 5 PhDs and over 7 MPhil students.

Dr. Mohsin Shah research is driven by the desire to find new therapeutics formulations with the long-term goal of treating metabolic and endocrine disorders, such as polycystic ovary syndrome, male/female infertility issues and associated stress and trauma. In the last decade of work experience in the field of endocrinology and reproductive physiology, he has expanded his research from basic sciences towards translational approaches and has recently designed and successfully conducted several clinical trials. His research lab works in collaboration with various well known clinicians and pharmaceutical companies to perform translational clinical research. He believes that scientific collaboration is an important aspect of science and extension of scientific linkages with a diverse community brings new ideas to the scientific enterprise. His research interest aims to understand the underlying cause of disease and to develop new nutraceuticals formulations to treat PCOS. As associate professor, department of physiology, he supervises basic, clinical, and translational research, formulates and integrates research activities. He also establishes programs that will foster public-private partnerships and commercialization of new, safe and effective formulation of drugs in order to ameliorate the heightened burden of fertility related issues. Dr. Mohsin is also the founder of MOSIK-BIO start-up; a registered firm, which is expected to provide healthcare awareness through engaging community, researchers, and educational activities toward a healthier life.

 

PROFESSIONAL HISTORY

 

Aug 22, 2024- present:               Research Professor, Department of Physiology, Institute of Basic Medical Science, Khyber Medical University, Peshawar, KPK, Pakistan

May 03, 2019- Aug 21, 2024:      Research Associate Professor, Department of Physiology, Institute of Basic Medical Science, Khyber Medical University, Peshawar, KPK, Pakistan

Jan 26, 2012-April 30, 2019:       Research Assistant Professor, Department of Physiology, Institute of Basic Medical Science, Khyber Medical University, Peshawar, KPK, Pakistan

Sep 1, 2010 to Jan 20, 2012:       Senior Researcher, Department of Life Sciences, Gyeongsang   National University, Gazwa Dong 351-411, Jinju, 660-701 South Korea

Apr 2, 2006 to Aug 20, 2006:      Lecturer Biochemistry, Hazara University, Mansehra NWFP Pakistan

 

EDUCATION:

                                    

Degree:                                    Doctor of Philosophy (Ph. D) (Science)

Year of Completion:                 Aug, 2010

University:                                Gyeongsang National University (South Korea)

Research Topic:                       “Amphiphilic Diblock Copolymer Nanoparticles Based on End-Capping of PHA Carboxy Terminal with mPEG: Preparation, Characterization, Enzymatic PHA Degradation and Their Application for Hydrophobic Drug Delivery System”

 

Degree:                                    Master of Philosophy (M. Phil) (Biochemistry/Molecular Biology)

Year of Completion:                 Feb, 2006

University:                                Quaid-i-Azam University, Islamabad (Pakistan)

Research Topic:                       “Studies on Quality Control of Haemorrhagic Septicaemia Vaccines” 

 

Degree:                                    Master of Science (M. Sc) (Biochemistry/Molecular Biology)

Year of Completion:                 Feb, 2004

University:                                Quaid-i-Azam University, Islamabad (Pakistan)


Degree:                                     Bachelor of Science (B. Sc) (Biochemistry)

Year of Completion:                 Aug, 2001

University:                                University of Peshawar Khyber Pukhtoonkhwa, Pakistan

Research Interests

PUBLICATIONS:

  1. Shah FA, Ullah R, Bin Dayel FF, Shah M*, Khan M, Rashid U, Khan MF, Rehman NU. Synthesis and Characterization of Dihydropyrimidine-2-One Derived Nanoparticles with Enhanced Anti-Bacterial Activity Against Pathogenic/Resistant Microorganisms. BioNanoScience, 16(5), 2026.
  2.  Bukhari SMS, Shah M*, Ali R, Rehman NU, Ahmad P, Shah FA. Ghrelin as a Candidate Molecule in Translational Pharmacology: Physiopharmacological Actions, Therapeutic Pros and Cons, and Delivery Challenges. Toxicology and Applied Pharmacology, 511, Article 117809, 2026.
  3. Zahra M, Shah M*, Iqbal F, Zubair T, Habib R, Zulfiqar F. Efficacy of combined nutritional and pharmacological interventions in PCOS: A six-month randomized controlled trial. Naunyn-Schmiedeberg's Arch Pharm, 15(04), 2026.
  4. Zahra M, Shah M*, Ahmad F, Iqbal N, Zulfiqar F, Tariq A. A randomized controlled trial comparing the efficacy of resveratrol combined with metformin versus resveratrol monotherapy in the management of polycystic ovary syndrome. Naunyn-Schmiedeberg's Arch Pharm, 15(04), 2026.
  5. Tirimzi SSA, Ahmed N, Shah I, Malik MO, Bukhari SMS, Laghari A, Azhar EI, Yasir M, Shah M*. Enhanced level of cardiac biomarkers (Troponin‑I, Atrial Natriuretic Peptide) and Angiotensin‑II in COVID‑19 hospitalized acute coronary syndrome patients. SN Compr Clin Med. 2025;7:150.
  6. Shah FA, Bukhari SMS, Emal E, Shah M*. Effects of integrative administration of acetyl-L-carnitine, arginine, and Co-Q10 in mitigating oxidative stress in over-weight/obese PCOS women. J of Appl Pharma Sci,15(04), 2025.
  7. Gul M, Khan H, Rauf B, Bukhari SMS, Ehtesham E, Malik MO, Shah FA, Alanazi FE, Shah M*. Comparative efficacy of combined myo‑inositol and D‑chiro inositol versus metformin across PCOS Phenotypes: enhancing ovarian function, ovulation, and stress response in a prospective clinical trial. Naunyn-Schmiedeberg's Arch Pharm, 2025.
  8. Sultan S, Zoofeen U, Shah I, Bukhari SMS, Sharif N, Bukhari SKS, Khan M, Habib SH, Shah FA, Alamoudi MK, Shah M*. Enhanced inflammatory and oxidative response mitigation by acetyl-L-carnitine in a rat model of pelvic inflammatory disease. Naunyn-Schmiedeberg's Arch Pharm, 2025.
  9. Farhat S, Shuaib A, Bukhari SMS, Shah FA, Naseeb IK, Ahmad S, Alamoudi MK, Shah M*. Ghrelin’s modulation of growth hormone secretagogue receptors in primary glioblastoma and meningioma: A comprehensive in-vitro study. Biochem Biophys Res Commun, 2025, 751.
  10. Jan A, Shah M*, Shah SA, Habib SH, Ehtesham E, Shah FA. Melatonin rescues pregnant female mice and their juvenile offspring from high fat diet-induced Alzheimer disease neuropathy. Heliyon 10, 2024, e36921.
  11. Zoofeen U, Shah M*, Sultan S, Ehtesham E, Shah I, Sharif S, Khan M, Shah FA. Punicalagin improves inflammation and oxidative stress in rat model of pelvic inflammatory disease. Nat Prod Res, 2024 Feb 8:1-7.
  12. Ramzan H, Shah M*, Ramzan F. Neurokinin B Administration Induces Dose Dependent Proliferation of Seminal Vesicles in Adult Rats. Current Protein & Peptide Science, 2024, 25, 339-352.
  13. Pitner I, Mikuš M, Goldštajn MS, Laganà AS, Chiantera V, Ferrari F, Shah M,  D’Alterio MN, Vitale SG, Angioni S. Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies. Gynecol Endocrinology, 2023, 39.
  14. Zubair A, Fatima S, Habib H, Nazli R, Shah I, Shah M. Effects of Oral Lipid‐Based nutritional supplements on appetite, energy intake, and lipid profile of moderately underweight children. Food Science & Nutrition. 2023 Feb;11(2):903-16.
  15. Aziz A, Shah M*, Siraj S, Iqbal W, Jan A, Khan I, Ahmed S, Vitale SG, Angioni S. Association of vitamin D deficiency and vitamin D receptor (VDR) gene single-nucleotide polymorphism (rs7975232) with risk of preeclampsia. Gynecological Endocrinology. 2023 Dec 14;39(1):2146089.
  16. Hassan S, Shah M*, Malik MO, Ehtesham E, Habib SH, Rauf B. Treatment with combined resveratrol and myoinositol ameliorates endocrine, metabolic alterations and perceived stress response in women with PCOS: a double-blind randomized clinical trial. Endocrine. 2023 Jan;79(1):208-20.
  17. Vitale SG, Fulghesu AM, Mikuš M, Watrowski R, D’Alterio MN, Lin LT, Shah M, Reyes-Muñoz E, Sathyapalan T, Angioni S. The Translational Role of MiRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review. Biomedicines. 2022 Jul 28;10(8):1816.
  18. Khan N, Shah M*, Malik MO, Badshah H, Habib SH, Shah I, Shah FA. The effects of tobacco and cannabis use on semen and endocrine parameters in infertile males. Human Fertility. 2021 Sep 28:1-9.
  19. Bibi S, Shah M*, Malik MO, Goosens KA. T3 is linked to stress‐associated reduction of prolactin in lactating women. Journal of Neuroendocrinology. 2021 Aug;33(8):e13003.
  20. Tauqir S, Israr M, Rauf B, Malik MO, Habib SH, Shah FA, Usman M, Raza MA, Shah I, Badshah H, Ehtesham E, Shah M*. Acetyl-L-carnitine ameliorates metabolic and endocrine alterations in women with PCOS: a double-blind randomized clinical trial. Advances in Therapy. 2021 Jul;38(7):3842-56.
  21. Tariq K, Fatima S, Nazli R, Habib SH, Shah M. Impact of lipid-based nutritional supplementation in primi-gravidas and its effect on maternal, birth and infant outcomes: a randomized controlled trial. Khyber Medical University Journal. 2021 Dec 31;14(4):187-92.
  22. Rehman F, Shah M*, Ali A, Rapisarda AM, Cianci A. Seroprevalence and risk factors of toxoplasma gondii infection in women with recurrent fetal loss from the province of khyber Pakhtunkhwa, Pakistan. Journal of Neonatal-Perinatal Medicine. 2021 Jan 1;14(1):115-21.
  23. Malik MO, Shah M*, Ullah N, Burgess JA, Goosens KA. Association of acyl-ghrelin with posttraumatic stress disorder in adolescents who experienced severe trauma. JAMA Network Open. 2020 Aug 3;3(8):e2013946-. 
  24. Rehman F, Shah M*, Ali A, Ahmad I, Sarwar MT, Rapisarda AM, Cianci A. Unpasteurised milk consumption as a potential risk factor for toxoplasmosis in females with recurrent pregnancy loss. Journal of Obstetrics and Gynaecology. 2020 Nov 16;40(8):1106-10.
  25. La Rosa VL, Shah M, Kahramanoglu I, Cerentini TM, Ciebiera M, Lin LT, Dirnfeld M, Minona P, Tesarik J. Quality of life and fertility preservation counseling for women with gynecological cancer: an integrated psychological and clinical perspective. Journal of Psychosomatic Obstetrics & Gynecology. 2020 Apr 2;41(2):86-92.
  26. Shah M*, Ali A, Malik MO, Rehman F, Badshah H, Ehtesham E, Vitale SG. Treatment with metformin and combination of metformin plus pioglitazone on serum levels of IL-6 and IL-8 in polycystic ovary syndrome: a randomized clinical trial. Hormone and Metabolic Research. 2019 Nov;51(11):714-22.
  27. Shah SS, Shah M*, Habib SH, Shah FA, Malik MO. Correlation of plasma kisspeptin with total testosterone levels in smokeless tobacco and smoking tobacco users in a healthy cohort: a cross‐sectional study. Andrologia. 2019 Nov;51(10):e13409.
  28. La Rosa VL, De Franciscis P, Barra F, Schiattarella A, Tropea A, Tesarik J, Shah M, Kahramanoglu I, Ponta M, Ferrero S. Sexuality in women with endometriosis: a critical narrative review. Minerva medica. 2019 Nov 11;111(1):79-89.
  29. La Rosa VL, De Franciscis P, Barra F, Schiattarella A, Török P, Shah M, Karaman E, Di Guardo F, Gullo G, Ponta M, Ferrero S. Quality of life in women with endometriosis: a narrative overview. Minerva Medica. 2019 Nov 12;111(1):68-78.
  30. Reyes-Muñoz E, Guardo FD, Ciebiera M, Kahramanoglu I, Sathyapalan T, Lin LT, Shah M, Karaman E, Fan S, Zito G, Noventa M. Diet and nutritional interventions with the special role of myo-inositol in gestational diabetes mellitus management. An evidence-based critical appraisal. Current Pharmaceutical Design. 2019 Jun 1;25(22):2467-73.
  31. Di Guardo F, Shah M, Cerana MC, Biondi A, Karaman E, Török P, Yela DA, Giampaolino P, Marín-Buck A, Laganà AS. Management of women affected by endometriosis: Are we stepping forward?. Journal of Endometriosis and Pelvic Pain Disorders. 2019 Jun;11(2):77-84.
  32. Tian B, Shah M, Choi MH, Rho JK, Lee SY, Yoon SC. Calcium involved directional organization of polymer chains in polyester nanogranules in bacterial cells. Scientific Reports. 2019 Mar 5;9(1):3429.
  33. Reyes-Muñoz E, Sathyapalan T, Rossetti P, Shah M, Long M, Buscema M, Valenti G, La Rosa VL, Cianci S, Vitale SG. Polycystic ovary syndrome: implication for drug metabolism on assisted reproductive techniques—a literature review. Advances in Therapy. 2018 Nov;35:1805-15.
  34. Mollaioli D, Lin LT, Shah M, Kahramaoglu I, Cerentini TM, Lordelo P, Arcieri S, Bonanno G, Zito G, LaRosa VL. Multidisciplinary management of sexual quality of life among menopausal women with urogynecological complains. Ital J Gynaecol Obstet. 2018;30(3):15-20.
  35. Salman H, Shah M*, Ali A, Aziz A, Vitale SG. Assessment of relationship of serum neurokinin-b level in the pathophysiology of pre-eclampsia: A case–control study. Advances in Therapy. 2018 Jul;35:1114-21.
  36. Yousufzai MI, Harmatz ES, Shah M*, Malik MO, Goosens KA. Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans. Translational psychiatry. 2018 Apr 11;8(1):74.
  37. Zahra M, Shah M*, Ali A, Rahim R. Effects of metformin on endocrine and metabolic parameters in patients with polycystic ovary syndrome. Hormone and Metabolic Research. 2017 Feb;49(02):103-8.
  38. Yasmin R, Shah M*, Khan SA, Ali R. Gelatin nanoparticles: A potential candidate for medical applications. Nanotechnology Reviews. 2017 Apr 1;6(2):191-207.
  39. Ahmad S, Shah M*, Ahmed J, Khan A, Hussain H, McVey M, Ali A. Association of hypoadiponectemia with smokeless/dipping tobacco use in young men. BMC Public Health. 2015 Dec;15(1):1-6.
  40. Ramzan MH, Ramzan M, Khan MM, Ramzan F, Wahab F, Khan MA, Jillani M, Shah M*. Human semen quality and sperm DNA damage assessed bycomet assay in clinical groups. Turkish journal of medical sciences. 2015;45(3):729-37.
  41. Ramzan MH, Ramzan M, Ramzan F, Wahab F, Jillani M, Khan MA, Shah M*. Insight into the serum kisspeptin levels in infertile males. Archives of Iranian medicine. 2015 Jan 1;18(1):0-.
  42. Rho JK, Choi MH, Gutierrez M, Tian B, Yoo T, Baek JE, Shah M, Yoon SC. Amorphous poly (3‐hydroxybutyrate) nanoparticles prepared with recombinant phasins and PHB depolymerase. Journal of Applied Polymer Science. 2014 Nov 15;131(22). 
  43. Shah M, Ullah N, Choi MH, Yoon SC. Nanoscale poly (4-hydroxybutyrate)-mPEG carriers for anticancer drugs delivery. Journal of Nanoscience and Nanotechnology. 2014 Nov 1;14(11):8416-21.
  44. Hassan S, Shah M, Yoon SC, Ullah I, Kim MO, Yoon J. Haptic guided virtual reality simulation for targeted drug delivery using nano-containers manipulation. Journal of biomedical nanotechnology. 2013 Jul 1;9(7):1190-4. 
  45. Shah M, Ullah N, Choi MH, Kim MO, Yoon SC. Amorphous amphiphilic P (3HV-co-4HB)-b-mPEG block copolymer synthesized from bacterial copolyester via melt transesterification: nanoparticle preparation, cisplatin-loading for cancer therapy and in vitro evaluation. European Journal of Pharmaceutics and Biopharmaceutics. 2012 Apr 1;80(3):518-27.
  46. Shah M, Choi MH, Ullah N, Kim MO, Yoon SC. Synthesis and characterization of PHV-block-mPEG diblock copolymer and its formation of amphiphilic nanoparticles for drug delivery. Journal of nanoscience and nanotechnology. 2011 Jul 1;11(7):570210. 
  47. Shah M, Naseer MI, Choi MH, Kim MO, Yoon SC. Amphiphilic PHA–mPEG copolymeric nanocontainers for drug delivery: preparation, characterization and in vitro evaluation. International Journal of Pharmaceutics. 2010 Nov 15;400(1-2):165-75.

Publications